ABMI

In clinical studies, emboli detection and statistics can easily be correlated with results on mortality, morbidity, and neuropsychological decline.

Various types of TCD data can be analyzed with the Embol-STATION™. The Station is used to study brain embolization, e.g. in the following cases:

• In atherosclerotic patients with unstable carotid plaques, pre-, post-, and per-operatively.
• During general cardio-vascular surgery, as well as stenting or other endovascular procedures.
• In patients with atrial fibrillation (AF) exposed to stroke.
• For patent foramen ovale (PFO) testing with saline injection.

The Embol-STATION is also used in assessing the efficiency of medications in terms of the reduction of the brain embolization rate.

TCD data collected during past clinical studies can be re-analyzed with the Embol-STATION. Thanks to the SSR® Technology, saturated Doppler signals can be restored to their full amplitudes, hence improving the quality of the Doppler signal, enhancing the display of micro embolic signals (MES) and increasing the detection rates for emboli.

Some specific Clinical Studies about the Embol-STATION™, co-written by clinical centers and the ABMI team, are listed below (click to download).


1. Solid or Gaseous Circulating Brain Emboli: Are They Separable by Transcranial Ultrasound?
Darbellay GA, Duff R, Vesin JM, Despland PA, Droste DW, Molina C, Serena J, Sztajzel R, Ruchat P, Karapanayiotides T, Kalangos A, Bogousslavsky J, Ringelstein EB, Devuyst G.
J Cereb. Blood Flow & Metab. 24:860-868(2004).


2. Automatic Classification of HITS into Artifacts or Solid or Gaseous Emboli by a Wavelet Representation Combined with Dual-Gate TCD. Devuyst G, Darbellay GA, Vesin JM, Kemeny V, Ritter M, Droste DW, Molina C, Serena J, Sztajzel R, Ruchat P, Lucchesi C, Dietler G, Ringelstein EB, Despland PA, Bogousslavsky J. Stroke. 2001;32(12):2803-2809.


3. HITS in Patients with Prosthetic Heart Valves: Do Numbers Predict the Solid or Gaseous Nature? T. Karapanayiotides, G.A. Darbellay, P. Ruchat, V. Kemeny, B. Piechowski-Jozwiak, J.M. Vesin, J. Bogousslavsky, P.A. Despland, G. Devuyst. 2004 CHUV, Karger AG, Basel.

4. Are Solid Microembolic Signals Predictive of Brain Ischemia during Carotid Endarterectomy? Devuyst G, Darbellay GA, Vesin JM, Kemeny V, Ritter M, Droste DW, Molina C, Serena J, Sztajzel R, Ruchat P, Lucchesi C, Dietler G, Ringelstein EB, Despland PA, Bogousslavsky J. In print


5. Solid/Gas Classification of In Vivo TCD Microembolic Signals via Inductive machine Learning. Lucchesi C, Darbellay GA, Devuyst G, Vesin JM, Bogousslavsky J and Dietler G, to be published


6. AUTOMATED OFF-LINE EMBOLI DETECTION AND SOLID/GAS DIFFERENTIATION THROUGH METACLASSIFIERS AND PROPOSITIONAL RULES. Dr. Claudio Lucchesi a), Dr. Léonard Studer a), Kacem Zaheg a), Dr Alix Herrmann a), Caroline Gonin a), Rémy Schuler a), Dr. Jean-Marc Vesin b), Dr. Patrick Ruchat c), Prof. Julien Bogousslavsky d) and Dr. Gérald Devuyst d).


7. ESTIMATION OF THE SIZES OF SOLID EMBOLI THROUGH TRANSCRANIAL DOPPLER ULTRASOUND: WILL THE TOTAL EMBOLIZED VOLUME TURN OUT TO BE THE MOST ACCURATE PREDICTOR OF EMBOLIC STROKE ? Dr. Claudio Lucchesi a), Caroline Gonin a), Kacem Zaheg a), Dr. Léonard Studer a), Dr Alix Herrmann a), Rémy Schuler a), Dr. Jean-Marc Vesin b), Prof. Julien Bogousslavsky c) and Dr. Gérald Devuyst c).



A large number of oral presentations have also been given at various international scientific conferences by the ABMI staff or by our clinical collaborators. These can be obtained on demand.