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Typical Applications of ABMI Technology

Clinical Focus

Peri-operative cerebral blood flow monitoring, e.g. in cardio-vascular open-sky surgery, and in particular in carotid endearterectomy (CAE)

  • Real-time follow-up of arterial cerebral blood flow (brain perfusion assessment, pulsatility index, etc),
  • Brain embolization monitoring,
  • Accurate differentiation between brain emboli and artifacts (movements, voice, tissue vibrations, other devices)
  • Accurate differentiation between solid and gaseous brain emboli,
  • Sizing of solid brain emboli and estimation of total embolic load (total embolized volume),
  • Adaptation of surgical procedures/techniques to reduce embolization (e.g. during artery dissection in CAE),
  • Setting up of a treatment standard (through anti-coagulant and/or neuroprotective drugs) for stroke prevention during surgery,
  • Brain embolization follow-up in the ICU/recovery room.

Blood flow monitoring during stenting/percutaneous procedures

During e.g.:

  • carotid stenting,
  • aortic arch procedures and
  • percutaneous interventions on the heart (valves stents, PFO closing, AF interventional treatment),

ABMI’s systems allow to monitor brain embolization by solid debris/clots, upon differentiating these from contrast media and air bubbles signals.

Real-time monitoring of stroke patients in the Stroke Unit and acute stroke management (drugs, thrombolysis, etc)

  • Real-time assessment of brain perfusion in the middle cerebral artery (MCA), and automatic alarms for the medical staff, in particular for patients suffering evolving stroke,
  • Real-time assessment of drug effects on brain perfusion, and management of acute stroke care,
  • Off-line and real-time monitoring of solid brain embolization, including the measurement of the total embolic load to the brain (as a function of the sizes of emboli),
  • Correlation between cerebral perfusion and arterial pressure and/or ICP.

Pre- and post-operative evaluation of patients with carotid stenosis

When coupled to the estimation of the degree of stenosis through ultrasound color imaging, ABMI software allows for

  • a precise assessment of the arterial plaque vulnerability, thereby for a more precise indication for surgery (e.g. in the case carotid stenoses ? 75% caused by unstable, embolizing plaques),
  • a precise post-op assessment of the remnant embolization after plaque removal, thus making it possible to better adapt medication.

Peri-operative blood flow/embolization monitoring and protection against fat emboli in large bone surgery/polytraumatic patients

Same techniques as in cardio-vascular surgery, but adapted to venous lung embolization (and to arterial brain embolization in PFO patients at risk),

Blood flow monitoring in extra-corporeal circulation (ECC) devices

  • Precise flow assessment in the ECC injection/rejection lines,
  • Precise monitoring of solid/gaseous emboli hitting patient.

Blood flow monitoring in renal dialysis and emergency or microdialysis equipment

  • Precise flow assessment in the dialysis injection/rejection lines
  • Precise monitoring of solid/gaseous emboli hitting patient
  • Early warning and emergency device stopping in case of blood foaming (in particular for newly marketed, home-based unsupervised dialysis systems)

Monitoring of deep venous thrombosis (DVT) patients at risk of embolization

Monitoring and early diagnosis of venous embolism (and arterial embolism in case of a PFO) in DVT patients (e.g. portable devices in commercial planes for the prevention of the “economy class syndrome”)

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